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Cruise ship in Panama Canal

Panama Canal Cruises from San Francisco

Two cruise lines offer cruises from San Francisco through the Panama Canal. The Canal is an engineering marvel and known as eighth wonder of the world. You'll pass through massive locks that lift or lower the ship. The area is also rich in exotic flora and fauna. The final destinations for these cruises from SF are New York or Florida. See the schedule of departures below.

The Panama Canal is a ship canal that connects the Pacific Ocean to the Atlantic. It is 48 miles long and is a vital route for international trade. Gatun Lake was created to reduce the amount of excavation required for the canal. The lake is 85 feet above sea level so locks at both ends raise and lower ships.

2019

18-day Panama Canal cruise on Oceania. One-way from San Francisco to Miami (Florida). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Acapulco (Mexico), Acajutla (El Salvador), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama), Cartagena (Colombia) and Havana (Cuba).
• 2019 departure: September 26.

15-day Panama Canal cruise on Princess Cruises. One-way from San Francisco to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), San Juan Del Sur (Nicaragua), Puntarenas (Costa Rica), Panama City (Panama), the Panama Canal and Cartagena (Colombia).
• 2019 departure: November 17.

2020

21-day Panama Canal cruise on Norwegian Cruise Line. One-way from San Francisco to New York. Visit Santa Barbara (California), Los Angeles (California), Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Ixtapa (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), Santa Marta (Colombia), Aruba, Curacao and Bonaire.
• 2020 departure: January 24.

20-day Panama Canal cruise on Oceania. One-way from San Francisco to New York. Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), Miami (Florida), Port Canaveral (Florida) and Charleston (South Carolina).
• 2020 departure: July 5.

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