P&O Cruises is a British cruise line that offers very few cruises from San Francisco to Australia or through the Panama Canal. See the schedule of departures below.
The P&O Cruise ship sailing out of San Francisco is the Arcadia, a mid-size ship exclusively for adults. Features include a pool with retractable roof, three dining venues, live entertainment and sports court. Read a review of the Arcadia.
23-night cruise to Australia on the Arcadia. One-way from San Francisco to Sydney (Australia). Visit Kona (Hawaii), Honolulu (Hawaii), Apia (Samoa), Suva (Fiji) and Port Vila (Vanuatu).
• 2027 departure: January 27.
26-night cruise to England on the Arcadia. One-way from San Francisco to Southampton (England). Visit Los Angeles (California), Manzanillo (Mexico), the Panama Canal, Curacao, Barbados and Ponta Delgada (Azores).
• 2026 departure: March 20.